AJ201 Reference Article

L.C. Bott, et al. A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy. Human Molecular Genetics. 2016 May.

BAER-101 Reference Articles and Presentations

A. Chappell, et al. BAER-101, a selective potentiator of a2- and a3-containing GABAA receptors, fully suppresses spontaneous cortical spike-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg (GAERS). American Epilepsy Society (AES) 2023 Annual Meeting.

T. L. Schaefer.,et al. GABAAAlpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome. Front Psychiatry 2021.

T. Nomura.,et al. Potentiating α2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet syndrome. JPhysiol 2019.

R. M. Hines., et al. Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin. NatCommun. 2018.

IV Tramadol Reference Articles

Green, J., et al. Real-World Data on Nonmedical Use of Tramadol from Patients Evaluated for Substance Abuse Treatment in the NAVIPPRO Addiction Severity Index – Multimedia Version (ASI-MV®). Drug Safety. 2020.

Iwanicki, J., et al. Tramadol Non-medical use in Four European Countries: A Comparative Analysis. Drug and Alcohol Dependence. December 2020.

Lu, L., et al. IV tramadol: A Novel Option for US Patients with Acute Pain – A Review of its Pharmacokinetics, Abuse Potential and Clinical Safety Record. Journal of Opioid Management. September 2020.

Lu, L., et al. Comparing the Pharmacokinetics of 2 Novel Intravenous Tramadol Dosing Regimens to Oral Tramadol: A Randomized 3-Arm Crossover Study. Clinical Pharmacology in Drug Development. October 2019.

Minkowitz , H., et al. Intravenous Tramadol is Effective in the Management of Postoperative Pain Following Abdominoplasty: A Three-Arm Randomized Placebo- and Active-Controlled Trial. Drugs in R&D. May 2020.

Minkowitz, H., et al. IV Tramadol – A New Treatment Option for Management of Post-Operative Pain in the U.S.: An Open-Label, Single-Arm, Safety Trial Including Various Types of Surgery. Journal of Pain Research. May 2020.

Reines, S., et al. Misuse of Tramadol in the United States: An Analysis of the National Survey of Drug Use and Health 2002-2017. Substance Abuse: Research and Treatment. June 2020.

Singla, N., et al. Efficacy and Safety of Intravenously Administered Tramadol in Patients with Moderate to Severe Pain Following Bunionectomy:  A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study. Pain and Therapy. July 2020.

Avenue Therapeutics White Paper. Pain Management in the Postoperative Setting. 2018.